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Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid(Gd- DOTA)is the first of a new class of macrocyclic paramagnetic magnetic resonance(MR)contrast agents(gadolinium cryptelates)to be used in clinical practice.Gadolinium-DOTA possesses relaxation properties similar to those of gadolinium diethylene triamine pentaacetic acid(Gd-DTPA).We report our initial clinical experience in 38 patients with intracranial lesions studied with MR before and after injection of Gd-DOTA.Diseases included primary and metastatic brain tumor,cerebral infarct,vascular malformation, meningioma,hemangiopericytoma,schwannoma,and pituitary macroadenoma. Gadolinium-DOTA was administered intravenously in a dosage of 0.1 mmol/kg body weight.All studies were performed on a superconductive 0.5 T system. As compared to noncontrast T1-and T2-weighted images(WI),Gd-DOTA enhanced T1 WI were useful in defining the anatomy of malignant intraaxial tumors (high-grade glioma,metastasis)and in tumor versus edema differentiation. Low-grade gliomas did not enhance;in these cases the precontrast T2- weighted sequence was found to be more informative.In post-operative patients,Gd-DOTA allowed us to demonstrate residual tumor or tumor recurrence.Extraaxial tumors(meningioma,hemangiopericytoma,neuroma) enhanced markedly,presumably reflecting tumor vascularity.In our experience,the use of Gd-DOTA improves the anatomic definition of cerebral lesions and in some cases increases both MR sensitivity and specificity.We found Gd-DOTA to be a well tolerated and effective paramagnetic contrast agent.Gadolinium-DOTA can be considered as an alternative water-soluble MR contrast agent to Gd-DTPA. |
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gadolinium
glioblastoma multiforme(astrocytoma Gr.III)
meningioma
MRI
MRI,abnormal
MRI,contrast enhanced
neoplasm,metastatic to CNS
neoplasm,primary intracerebral
neoplasm,primary intracranial
neoplasm,primary of CNS
neuroma
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